Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19.

ABSTRACT: The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue provides crucial insights into the pathophysiology of severe disease. From basic histology to state-of-the-art multiparameter digital pathology technologies, post-mortem lung tissue provides snapshots of tissue architecture, and resident and inflammatory cell phenotypes and composition at the time of death. Contrary to early assumptions that COVID-19 in the lungs is a uniform disease, post-mortem findings have established a high degree of disease heterogeneity. Classic diffuse alveolar damage represents just one phenotype, with disease divisible by early and late progression as well as by pathophysiological process. A distinct lung tissue state occurs with secondary infection; extrapulmonary causes

SUBMITTER: Milross L 

PROVIDER: S-EPMC8641959 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature