Phenotypic and Genotypic Associations Between Migraine and Lipoprotein Subfractions.

ABSTRACT:

Background and objective

To evaluate phenotypic and genetic relationships between migraine and lipoprotein subfractions.

Methods

We evaluated phenotypic associations between migraine and 19 lipoprotein subfraction measures in the Women's Genome Health Study (n = 22,788). We then investigated genetic relationships between these traits using summary statistics from the International Headache Genetics Consortium for migraine (n_case = 54,552, n_control = 297,970) and combined summary data for lipoprotein subfractions (n up to 47,713).

Results

There was a significant phenotypic association (odds ratio 1.27 [95% confidence interval 1.12-1.44]) and a significant genetic correlation at 0.18 (p = 0.001) between migraine and triglyceride-rich lipopro

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8641972 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature