Aldehyde dehydrogenase 1 (ALDH1) immunostaining in axillary lymph node metastases is an independent prognostic factor in ALDH1-positive breast cancer.

ABSTRACT:

Objective

To determine whether aldehyde dehydrogenase 1 (ALDH1) immunostaining in axillary lymph node metastases in patients with breast cancer is associated with poor clinical prognosis.

Methods

This retrospective study reviewed data from the medical records of patients with immunohistochemistry-confirmed invasive ductal carcinoma (IDC) and 1-3 metastatic lymph nodes in the ipsilateral axilla between December 2012 and July 2015. The association between ALDH1 immunostaining in axillary lymph node metastases and clinical parameters and prognosis was analysed using χ²-test, Kaplan-Meier survival analysis, univariate and multivariate Cox regression analyses.

Results

A total of 229 patients with IDC were enrolled in the study. The median follow-up was 61 months

SUBMITTER: Guan X 

PROVIDER: S-EPMC8642120 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature