Exploring relationships between alcohol consumption, inflammation, and brain structure in a heavy drinking sample.

ABSTRACT:

Background

Chronic alcohol consumption is associated with structural brain changes and increased inflammatory signaling throughout the brain and body. Increased inflammation in the brain has been associated with structural damage. Recent studies have also shown that neurofilament light polypeptide (NfL) is released into the systemic circulation following neuronal damage. Although NfL has thus been proposed as a biomarker for neurodegenerative diseases, its connection to alcohol use disorder has not been explored. For this secondary data analysis, we proposed a conceptual model linking alcohol consumption, the pro-inflammatory cytokine IL-6, brain structure, and NfL in heavy drinking participants.

Methods

Of the 182 individuals enrolled in this study, 81 participants had usab

SUBMITTER: Karoly HC 

PROVIDER: S-EPMC8642310 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature