Long-term neurocognitive and quality of life outcomes in survivors of pediatric hematopoietic cell transplant.

ABSTRACT:

Purpose

Pediatric patients who undergo hematopoietic cell transplant (HCT) are at risk for neurocognitive impairments, which can impact quality of life. Given limited long-term studies, we aimed to characterize the late neurocognitive outcomes in a cohort of pediatric HCT survivors.

Methods

Eligible survivors (HCT at age < 21 year and ≥ 1 year post-HCT) completed a 60-question survey of neurocognitive function and quality of life, which included the Childhood Cancer Survivor Study Neurocognitive Questionnaire (CCSS-NCQ) and the Neuro-Quality of Life Cognitive Function Short Form (Neuro-QoL). Analyses of risk factors included univariate comparisons and multivariable logistic regression.

Results

Participants (n = 199, 50.3% female, 53.3% acute leukemia, 87.9% allogeneic

SUBMITTER: Wu NL 

PROVIDER: S-EPMC8642486 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature