Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells.

ABSTRACT: Tissue-resident memory CD8 T cells (CD8 T_RM) are critical for maintaining barrier immunity. CD8 T_RM have been mainly studied in the skin, lung and gut, with recent studies suggesting that the signals that control tissue residence and phenotype are highly tissue dependent. We examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B⁺ and TCF-1^- To address if this phenotype is driven by CVT tissue residence, we used a mouse model to control for environmental factors. Using localized and systemic infection models, we found that CD8 T_RM in the mouse CVT gradually acquired a granzyme B⁺, TCF-1^- phenotype as seen in human CVT. In contrast to CD8 T_RM

SUBMITTER: Dave VA 

PROVIDER: S-EPMC8642491 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature