Tripodalsporormielones A-C, unprecedented cage-like polyketides with complex polyvdent bridged and fused ring systems.

ABSTRACT: A chemical investigation on Sporormiella sp. led to the isolation and structural elucidation of tripodalsporormielones A-C (1-3), a new class of polyketide possessing unprecedented cage-like skeletons with polyvdent bridged and fused ring systems. These polyketides with cage-like skeletons were characterized as a high non-protonated carbon-containing system, which resulted in few HMBC correlations observed and made the accurate structures hard to be obtained by NMR. Especially, some signals of non-protonated sp ² carbons are weak and even unobservable in compound 1. In order to establish the structure of 1, the calculated NMR with DP4 evaluation was applied to determine the structure from the plausible structure candidates obtained from

SUBMITTER: Chen G 

PROVIDER: S-EPMC8642606 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature