Unveiling antioxidant and anti-cancer potentials of characterized Annona reticulata leaf extract in 1,2-dimethylhydrazine-induced colorectal cancer in Wistar rats.

ABSTRACT:

Background

Colorectal cancer (CC) is the third most common cancer in the world. Annona reticulata (AR) also known as bullock's heart, is a traditional herb. AR leaf extract was initially investigated for its anti-bacterial, anti-inflammatory, anti-malarial, anti-helminthic, anti-stress, and wound healing properties. Only a few in vitro cancer studies have been conducted on AR. Although few studies have linked AR leaf extract to many cancers, comprehensive studies addressing regulation, biological functions, and molecular mechanisms leading to CC pathogenesis are clearly lacking.

Objectives

The present study aimed to explore the antioxidant and anti-cancer potentials of AR leaf extract in CC.

Materials and methods

The MTT assay was used to test the anti-proliferative a

SUBMITTER: Khan G N 

PROVIDER: S-EPMC8642649 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature