Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity.

ABSTRACT:

Background

Cisplatin is extensively used in treating cancers, and its primary side-effect is nephrotoxicity. It accumulates in proximal convoluted tubules where it promotes cellular damage by oxidative stress, apoptosis, and inflammation, etc. In Unani medicine, Tukhm-e-Karafs(Apium graveolens L.) (TK) is mentioned in the literature to manage various kidney ailments due to its diuretic and deobstruent activities.

Objective

To investigate the nephroprotective effects of powder of TK in Cisplatin-induced nephrotoxicity in an animal model and to validate the Unani claim of its nephroprotective action.

Material and methods

In curative protocol, cisplatin (5 mg/kg body weight i.p) was administered on day one and powder of TK (500 and 1000 mg/kg p.o.) from the sixth day onw

SUBMITTER: Naushad M 

PROVIDER: S-EPMC8642661 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature