Dipeptidyl peptidase-IV inhibitory action of Calebin A: An in silico and in vitro analysis.

ABSTRACT:

Background

Dipeptidyl peptidase-IV (DPP-IV) inhibitors, the enhancers of incretin are used for the treatment of diabetes. The non-glycaemic actions of these drugs (under developmental stage) also proved that repurposing of these molecules may be advantageous for other few complicated disorders like cardiovascular diseases, Parkinson's disease, Alzheimer's disease, etc. OBJECTIVE: The present study was aimed to investigate the DPP-IV inhibitory potential of Calebin-A, one of the constituents of Curcuma longa.

Material and methods

The phytoconstituent was subjected for various in silico studies (using Schrödinger Suite) like, Docking analysis, molecular mechanics combined with generalized Born model and solvent accessibility method (MMGBSA) and Induced fit docking (IFD) after

SUBMITTER: Chalichem NSS 

PROVIDER: S-EPMC8642699 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature