Expression profile of RNA binding protein in cervical cancer using bioinformatics approach.

ABSTRACT:

Background

It has been demonstrated by studies globally that RNA binding proteins (RBPs) took part in the development of cervical cancer (CC). Few studies concentrated on the correlation between RBPs and overall survival of CC patients. We retrieved significant DEGs (differently expressed genes, RNA binding proteins) correlated to the process of cervical cancer development.

Methods

Expressions level of genes in cervical cancer and normal tissue samples were obtained from GTEx and TCGA database. Differently expressed RNA binding proteins (DEGs) were retrieved by Wilcoxon sum-rank test. ClusterProfiler package worked in R software was used to perform GO and KEGG enrichment analyses. Univariate proportional hazard cox regression and multivariate proportional hazard cox regressi

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8642772 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature