Identifying Diagnostic MicroRNAs and Investigating Their Biological Implications in Rectal Cancer.

ABSTRACT:

Importance

Accurate clinical staging is important in rectal cancer because it determines the appropriate treatment and prognosis. Despite the use of multiple diagnostic imaging tools, it is sometimes difficult to clinically distinguish stage I tumors from stage II or III locally advanced disease. Identification of differentiating microRNAs (miRNAs) between these 2 groups may improve the clinical diagnostic power and provide insight into the biology of tumor progression.

Objectives

To investigate differences in the expression of miRNAs in stage I vs stage II or III rectal cancers and integrate matched mRNA profiling data to identify possible functional roles of these miRNAs.

Design, setting, and participants

The primary tumor specimens from patients who were enrolled i

SUBMITTER: Kim JK 

PROVIDER: S-EPMC8642786 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature