Respiratory burden in obese and young asthmatics: a study of diaphragmatic kinetics.

ABSTRACT:

Objective

The aim of this study was to assess the diaphragm kinetics, respiratory function, and serum dosage of leptin and inflammatory cytokines (IL-6 and TNF-α) in three clinical groups: obese, asthmatic, and healthy.

Methods

This is a clinical exploratory study performed on 73 youths (12-24 years of age, 42.5% male) allocated into three groups: obesity (OG, n=33), body mass index (BMIz-score) ≥ +2, asthmatic (AG, n=26) controlled mild asthmatics, classified by GINA, and Healthy Control Group (CG, n=14). The participants were subjected to diaphragmatic ultrasound, spirometry, maximal respiratory pressure, serum leptin levels, and IL-6 and TNF-α whole blood cell culture levels.

Results

Diaphragm thickness was higher in OG in comparison to AG and CG (2.0±0.4 vs 1.7±0.

SUBMITTER: Tenorio LHS 

PROVIDER: S-EPMC8642816 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature