Modeling in the Time of COVID-19: Statistical and Rule-based Mesoscale Models.

ABSTRACT: We present a new technique for the rapid modeling and construction of scientifically accurate mesoscale biological models. The resulting 3D models are based on a few 2D microscopy scans and the latest knowledge available about the biological entity, represented as a set of geometric relationships. Our new visual-programming technique is based on statistical and rule-based modeling approaches that are rapid to author, fast to construct, and easy to revise. From a few 2D microscopy scans, we determine the statistical properties of various structural aspects, such as the outer membrane shape, the spatial properties, and the distribution characteristics of the macromolecular elements on the membrane. This information is utilized in the construction of the 3D model. Once all the imaging evidenc

SUBMITTER: Nguyen N 

PROVIDER: S-EPMC8642830 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature