MMP12 knockout prevents weight and muscle loss in tumor-bearing mice.

ABSTRACT:

Background

Colorectal cancer is a malignant gastrointestinal cancer, in which some advanced patients would develop cancer cachexia (CAC). CAC is defined as a multi-factorial syndrome characterized by weight loss and muscle loss (with or without fat mass), leading to progressive dysfunction, thereby increasing morbidity and mortality. Apc^Min/+ mice develop spontaneous intestinal adenoma, which provides an established model of colorectal cancer for CAC study. Upon studying the Apc^Min/+ mouse model, we observed a marked decrease in weight gain beginning around week 15. Such a reduction in weight gain was rescued when Apc^Min/+ mice were crossed with MMP12^-/- mice, indicating that MMP12 has a role in age-related Apc^Min/+-associated

SUBMITTER: Jiang L 

PROVIDER: S-EPMC8642861 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature