The application of human periodontal ligament stem cells and biomimetic silk scaffold for in situ tendon regeneration.

ABSTRACT:

Background

With the development of tissue engineering, enhanced tendon regeneration could be achieved by exploiting suitable cell types and biomaterials. The accessibility, robust cell amplification ability, superior tendon differentiation potential, and immunomodulatory effects of human periodontal ligament stem cells (hPDLSCs) indicate their potential as ideal seed cells for tendon tissue engineering. Nevertheless, there are currently no reports of using PDLSCs as seed cells. Previous studies have confirmed the potential of silk scaffold for tendon tissue engineering. However, the biomimetic silk scaffold with tendon extracellular matrix (ECM)-like structure has not been systematically studied for in situ tendon regeneration. Therefore, this study aims to evaluate the effects of

SUBMITTER: Chen J 

PROVIDER: S-EPMC8642874 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature