CircSERPINA3 regulates SERPINA3-mediated apoptosis, autophagy and aerobic glycolysis of prostate cancer cells by competitively binding to MiR-653-5p and recruiting BUD13.

ABSTRACT:

Background

Prostate cancer (PCa) belongs to an epithelial malignancy that occurs in the prostate gland and is the most common malignancy of the male genitourinary system. Referring to related literature, circSERPINA3 has been reported to be up-regulated in PCa. However, its biological function remains unclear.

Purpose

This study aimed to reveal the specific role and relevant molecular mechanism of circSERPINA3 in PCa.

Methods

RT-qPCR was used to examine gene expression and functional analyses were conducted to verify the effect of circSERPINA3 on cell apoptosis, autophagy and aerobic glycolysis in PCa cells. Mechanism assays were applied to evaluate the relationship among circSERPINA3/miR-653-5p/SERPINA3/BUD13.

Results

CircSERPINA3 was verified to be up-regulat

SUBMITTER: Xing Z 

PROVIDER: S-EPMC8642898 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature