YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.

ABSTRACT:

Background

Glioma is a common type of malignant brain tumor with a high mortality and relapse rate. The endosomal sorting complex required for transport (ESCRT) has been reported to be involved in tumorigenesis. However, the molecular mechanisms have not been clarified.

Methods

Bioinformatics was used to screen the ESCRT subunits highly expressed in glioma tissues from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The function of the ESCRT subunits in glioma cells was examined in vitro. Transcriptome sequencing analyzed the target genes and signaling pathways affected by the ESCRT subunit. Finally, the relationship between m⁶A (N⁶-methyladenosine) modification and high expression of the ESCRT subunit was studied.

Results

SUBMITTER: Zhu X 

PROVIDER: S-EPMC8642909 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature