Genetic association tests in family samples for multi-category phenotypes.

ABSTRACT:

Background

Advancements in statistical methods and sequencing technology have led to numerous novel discoveries in human genetics in the past two decades. Among phenotypes of interest, most attention has been given to studying genetic associations with continuous or binary traits. Efficient statistical methods have been proposed and are available for both types of traits under different study designs. However, for multinomial categorical traits in related samples, there is a lack of efficient statistical methods and software.

Results

We propose an efficient score test to analyze a multinomial trait in family samples, in the context of genome-wide association/sequencing studies. An alternative Wald statistic is also proposed. We also extend the methodology to be applicable to

SUBMITTER: Wang S 

PROVIDER: S-EPMC8642939 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature