Novel approaches in cancer treatment: preclinical and clinical development of small non-coding RNA therapeutics.

ABSTRACT: Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in size and function able to inhibit gene expression based on their complementarity with mRNA sequences, inducing the degradation of the transcript or the inhibition of their translation.siRNAs bind specifically to a single gene location by sequence complementarity and regulate gene expression by specifically targeting transcription units via posttranscriptional gene silencing. miRNAs can regulate the expression of different gene targets through their imperfect base pairing.This process - known as RNA interference (RNAi) - modulates transcription in order to maintain a correct physiological environment, playing a role in almost the totality of the cellular pathways.siRNAs have been evolutionary evolved for

SUBMITTER: Cuciniello R 

PROVIDER: S-EPMC8642961 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature