Neuroprotective effects of long noncoding RNAs involved in ischemic postconditioning after ischemic stroke.

ABSTRACT: During acute reperfusion, the expression profiles of long noncoding RNAs in adult rats with focal cerebral ischemia undergo broad changes. However, whether long noncoding RNAs are involved in neuroprotective effects following focal ischemic stroke in rats remains unclear. In this study, RNA isolation and library preparation was performed for long noncoding RNA sequencing, followed by determining the coding potential of identified long noncoding RNAs and target gene prediction. Differential expression analysis, long noncoding RNA functional enrichment analysis, and co-expression network analysis were performed comparing ischemic rats with and without ischemic postconditioning rats. Rats were subjected to ischemic postconditioning via the brief and repeated occlusion of the middle cerebral a

SUBMITTER: Ma W 

PROVIDER: S-EPMC8643058 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature