Quercetin Improves Mitochondrial Function and Inflammation in H₂O₂-Induced Oxidative Stress Damage in the Gastric Mucosal Epithelial Cell by Regulating the PI3K/AKT Signaling Pathway.

ABSTRACT: Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders, the therapeutic strategy of which it is limited due to its complex pathogenesis. Oxidative stress-induced damage in gastric mucosal epithelial cells is related to the pathogenesis and development of FD. Quercetin (Que) is one of the active ingredients of Zhishi that showed antioxidant, antiapoptotic, and anti-inflammatory effects. The aim of this study is to investigate the effect of Que on oxidative stress-induced gastric mucosal epithelial cells damage and its underlying molecular mechanism. The gastric mucosal epithelial cell line GES-1 was treated with 200 μM of H₂O₂ to construct an oxidative stress-induced damage model. The H₂O₂ cells were then

SUBMITTER: Yao X 

PROVIDER: S-EPMC8643250 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature