Metallaphotoredox-enabled deoxygenative arylation of alcohols.

ABSTRACT: Metal-catalysed cross-couplings are a mainstay of organic synthesis and are widely used for the formation of C-C bonds, particularly in the production of unsaturated scaffolds¹. However, alkyl cross-couplings using native sp³-hybridized functional groups such as alcohols remain relatively underdeveloped². In particular, a robust and general method for the direct deoxygenative coupling of alcohols would have major implications for the field of organic synthesis. A general method for the direct deoxygenative cross-coupling of free alcohols must overcome several challenges, most notably the in situ cleavage of strong C-O bonds³, but would allow access to the vast collection of commercially available, structurally diverse alcohols as coupling partner

SUBMITTER: Dong Z 

PROVIDER: S-EPMC8643278 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature