Lung Cancer as a Subsequent Malignant Neoplasm in Survivors of Childhood Cancer.

ABSTRACT:

Background

Lung cancer, the most common cause of cancer-related death in adults, has not been well studied as a subsequent malignant neoplasm (SMN) in childhood cancer survivors. We assessed prevalence, risk factors, and outcomes for lung SMN in the Childhood Cancer Survivor Study (CCSS) cohort.

Methods

Among 25,654 5-year survivors diagnosed with childhood cancer (<21 years), lung cancer was self-reported and confirmed by pathology record review. Standardized incidence ratios (SIR) and cumulative incidences were calculated, comparing survivors to the general population, and hazard ratios (HR) were estimated using Cox regression for diagnosis and treatment exposures.

Results

Forty-two survivors developed a lung SMN [SIR, 4.0; 95% confidence interval (CI), 2.9-5.4] wit

SUBMITTER: Ghosh T 

PROVIDER: S-EPMC8643305 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature