Dietary Advanced Glycation End-Products and Mortality after Breast Cancer in the Women's Health Initiative.

ABSTRACT:

Background

Advanced glycation end-products (AGE) are formed through nonenzymatic glycation of free amino groups in proteins or lipid. They are associated with inflammation and oxidative stress, and their accumulation in the body is implicated in chronic disease morbidity and mortality. We examined the association between postdiagnosis dietary N^ε-carboxymethyl-lysine (CML)-AGE intake and mortality among women diagnosed with breast cancer.

Methods

Postmenopausal women aged 50 to 79 years were enrolled in the Women's Health Initiative (WHI) between 1993 and 1998 and followed up until death or censoring through March 2018. We included 2,023 women diagnosed with first primary invasive breast cancer during follow-up who completed a food frequency questionnaire (FFQ) aft

SUBMITTER: Omofuma OO 

PROVIDER: S-EPMC8643311 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature