Gallstone Disease and Risk of Conventional Adenomas and Serrated Polyps: A Prospective Study.

ABSTRACT:

Background

Gallstone disease has been associated with colorectal cancer and some form of polyps, although the findings are inconclusive. It remains unknown whether gallstone disease influences the initiation of colorectal cancer.

Methods

We prospectively assessed the association of gallstone disease with risk of colorectal cancer precursors, including conventional adenomas and serrated polyps, in the Nurses' Health Study (1992-2012), the Nurses' Health Study II (1991-2011), and the Health Professionals Follow-up Study (1992-2012). Gallstone diseases were assessed using biennial follow-up questionnaires. Self-reported polyp diagnosis was confirmed by review of medical records. Logistic regression models were used to calculate the ORs with adjustment for smoking and other pote

SUBMITTER: Polychronidis G 

PROVIDER: S-EPMC8643323 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature