Hypervitaminosis A in Pediatric Patients With Advanced Chronic Kidney Disease.

ABSTRACT:

Objective

Hypervitaminosis A is well-described but overlooked in chronic kidney disease (CKD) and has been associated with hypercalcemia, contributing to mineral bone disease. Our objective is to assess prevalence of hypervitaminosis A and its association with bone health in an advanced-CKD population.

Methods

We performed a retrospective review of 58 children with CKD 4-5 to examine the association between vitamin A levels and bone health and compared these values between a primarily formula-fed (FF) and nonprimarily formula-fed cohort (NFF).

Results

Fifty-six of 58 patients (97%) had hypervitaminosis A with a mean vitamin A level of 1,475 ± 597 mcg/dL. When compared with the upper limit of normal vitamin A level for age, the FF group's vitamin A level was 2.9x upper

SUBMITTER: Harris M 

PROVIDER: S-EPMC8643365 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature