Reward-Related Neural Circuitry in Depressed and Anxious Adolescents: A Human Connectome Project.

ABSTRACT:

Objective

Although depression and anxiety often have distinct etiologies, they frequently co-occur in adolescence. Recent initiatives have underscored the importance of developing new ways of classifying mental illness based on underlying neural dimensions that cut across traditional diagnostic boundaries. Accordingly, the aim of the study was to clarify reward-related neural circuitry that may characterize depressed-anxious youth.

Method

The Boston Adolescent Neuroimaging of Depression and Anxiety Human Connectome Project tested group differences regarding subcortical volume and nucleus accumbens activation during an incentive processing task among 14- to 17-year-old adolescents presenting with a primary depressive and/or anxiety disorder (n = 129) or no lifetime history of

SUBMITTER: Auerbach RP 

PROVIDER: S-EPMC8643367 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature