Virologic Features of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children.

ABSTRACT:

Background

Data on pediatric coronavirus disease 2019 (COVID-19) has lagged behind adults throughout the pandemic. An understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral dynamics in children would enable data-driven public health guidance.

Methods

Respiratory swabs were collected from children with COVID-19. Viral load was quantified by reverse-transcription polymerase chain reaction (RT-PCR); viral culture was assessed by direct observation of cytopathic effects and semiquantitative viral titers. Correlations with age, symptom duration, and disease severity were analyzed. SARS-CoV-2 whole genome sequences were compared with contemporaneous sequences.

Results

One hundred ten children with COVID-19 (median age, 10 years [range, 2 weeks-2

SUBMITTER: Yonker LM 

PROVIDER: S-EPMC8643403 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature