Diagnostic accuracy and clinical impact of [18F]FET PET in childhood CNS tumors.

ABSTRACT:

Background

Central nervous system (CNS) tumors cause the highest death rates among childhood cancers, and survivors frequently have severe late effects. Magnetic resonance imaging (MRI) is the imaging modality of choice, but its specificity can be challenged by treatment-induced signal changes. In adults, O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) PET can assist in interpreting MRI findings. We assessed the clinical impact and diagnostic accuracy of adding [18F]FET PET to MRI in children with CNS tumors.

Methods

A total of 169 [18F]FET PET scans were performed in 97 prospectively and consecutively included patients with known or suspected childhood CNS tumors. Scans were performed at primary diagnosis, before or after treatment, or at relapse.

Results

Adding [18F]FE

SUBMITTER: Marner L 

PROVIDER: S-EPMC8643444 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature