Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders.

ABSTRACT: The resting QT interval, an electrocardiographic (ECG) measure of ventricular myocardial repolarization, is a heritable risk marker of cardiovascular mortality, but the mechanisms remain incompletely understood. Previously reported candidate genes have provided insights into the regulatory mechanisms of the QT interval. However, there are still important knowledge gaps. We aimed to gain new insights by (i) providing new candidate genes, (ii) identifying pleiotropic associations with other cardiovascular traits, and (iii) scanning for sexually dimorphic genetic effects. We conducted a genome-wide association analysis for resting QT interval with ~9.8 million variants in 52 107 individuals of European ancestry without known cardiovascular disease from the UK Biobank. We identified 40 loci, 1

SUBMITTER: van Duijvenboden S 

PROVIDER: S-EPMC8643508 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature