Movement-related EEG signatures associated with freezing of gait in Parkinson's disease: an integrative analysis.

ABSTRACT: Freezing of gait is the most severe gait deficit associated with Parkinson's disease and significantly affects patients' independence and consequently their quality of life. The lack of a clear understanding of its underlying neurophysiological mechanism has resulted in limited effectiveness of the current treatment options. In this study, we investigated EEG features over (pre-)supplementary motor area and primary motor cortex during a simple cue-based ankle dorsiflexion movement. These features include movement-related cortical potentials (0.05-5 Hz) and brain oscillations (1-50 Hz). Electromyogram signal from the tibialis anterior muscle of the dominant foot was used to determine the movement onset. The EEG features before, during and following the onset of the movement were compared am

SUBMITTER: Karimi F 

PROVIDER: S-EPMC8643573 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature