Modulating the chemo-mechanical response of structured DNA assemblies through binding molecules.

ABSTRACT: Recent advances in DNA nanotechnology led the fabrication and utilization of various DNA assemblies, but the development of a method to control their global shapes and mechanical flexibilities with high efficiency and repeatability is one of the remaining challenges for the realization of the molecular machines with on-demand functionalities. DNA-binding molecules with intercalation and groove binding modes are known to induce the perturbation on the geometrical and mechanical characteristics of DNA at the strand level, which might be effective in structured DNA assemblies as well. Here, we demonstrate that the chemo-mechanical response of DNA strands with binding ligands can change the global shape and stiffness of DNA origami nanostructures, thereby enabling the systematic modulation of

SUBMITTER: Lee C 

PROVIDER: S-EPMC8643692 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature