Clinical outcomes and survival following lung transplantation in patients with pulmonary Langerhans cell histiocytosis.

ABSTRACT:

Background and objective

Disease-specific outcomes following lung transplantation (LT) in patients with pulmonary Langerhans cell histiocytosis (PLCH) are not well established. We queried the Organ Procurement and Transplantation Network database to identify adult PLCH patients who had undergone LT in the United States.

Methods

Overall survival data were analysed with Kaplan-Meier curves. Cox proportional hazard model was used to determine the effect of demographic, clinical and physiological variables on post-transplant survival.

Results

A total of 87 patients with PLCH underwent LT in the United States between October 1987 and June 2017, accounting for 0.25% of the total LT during this period. The mean age at LT for PLCH patients was 49 years (range: 19-67 years), w

SUBMITTER: Wajda N 

PROVIDER: S-EPMC8643712 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature