Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans.

ABSTRACT:

Background

Yeasts of the CTG-clade lineage, which includes the human-infecting Candida albicans, Candida parapsilosis and Candida tropicalis species, are characterized by an altered genetic code. Instead of translating CUG codons as leucine, as happens in most eukaryotes, these yeasts, whose ancestors are thought to have lost the relevant leucine-tRNA gene, translate CUG codons as serine using a serine-tRNA with a mutated anticodon, [Formula: see text]. Previously reported experiments have suggested that 3-5% of the CTG-clade CUG codons are mistranslated as leucine due to mischarging of the [Formula: see text]. The mistranslation was suggested to result in variable surface proteins explaining fast host adaptation and pathogenicity.

Results

In this study, we reassess this pot

SUBMITTER: Muhlhausen S 

PROVIDER: S-EPMC8645108 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature