Variability in oral antibiotic step-down therapy in the management of Gram-negative bloodstream infections.

ABSTRACT: There are important gaps in the literature regarding the role and timing of oral therapy for Gram-negative bloodstream infections (GN-BSIs). To better understand contemporary management practices involving oral step-down in GN-BSI, we conducted an international survey of infectious diseases (ID) specialists. We developed and disseminated an online survey to ID specialists to assess practice patterns involving oral step-down in GN-BSIs, including providers from six continents and 28 countries. χ² tests and generalised estimating equations were used to identify factors associated with oral step-down. In total, 277 ID specialists completed the survey (64% physicians, 31% pharmacists). Relative to a line source, oral step-down was more common in abdominal [OR = 1.96 (95% CI 1.48-2.6

SUBMITTER: Thaden JT 

PROVIDER: S-EPMC8645249 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature