β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score-matched cohort study.

ABSTRACT:

Objectives

To examine the association between β-blocker prescription and first primary-care consultation for knee OA, hip OA, knee pain and hip pain.

Methods

Data source: Clinical Practice Research Datalink. Participants aged ≥40 years in receipt of new oral β-blocker prescriptions were propensity score (PS) matched to an unexposed control. Cox proportional hazard ratios (HRs) and 95% CIs were calculated, and adjusted for non-osteoporotic fractures, number of primary-care consultations for knee or hip injury, and, the number of primary-care consultations, out-patient referrals and hospitalizations in the 12 months preceding cohort entry. Analysis was stratified according to β-blocker class and for commonly prescribed drugs. P < 0.05 was considered statistically significant.<

SUBMITTER: Nakafero G 

PROVIDER: S-EPMC8645269 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature