Establishment and Characterization of a Novel Dedifferentiated Chondrosarcoma Cell Line DDCS2.

ABSTRACT:

Background

The dedifferentiated variant of chondrosarcoma is highly aggressive and carries an especially grim prognosis. While chemotherapeutics has failed to benefit patients with dedifferentiated chondrosarcoma significantly, preclinical chemosensitivity studies have been limited by a scarcity of available cell lines. There is, therefore, an urgent need to expand the pool of available cell lines.

Methods

We report the establishment of a novel dedifferentiated chondrosarcoma cell line DDCS2, which we isolated from the primary tumor specimen of a 60-year-old male patient. We characterized its short tandem repeat (STR) DNA profile, growth potential, antigenic markers, chemosensitivity, and oncogenic spheroid and colony-forming capacity.

Results

DDCS2 showed a spindle t

SUBMITTER: Li X 

PROVIDER: S-EPMC8645311 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature