TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.

ABSTRACT: Metastasis is the leading driver of cancer-related death. Tumor cell plasticity associated with the epithelial-mesenchymal transition (EMT), an embryonic program also observed in carcinomas, has been proposed to explain the colonization of distant organs by the primary tumor cells. Many studies have established correlations between EMT marker expression in the primary tumor and metastasis in vivo. However, the longstanding model of EMT-transitioned cells disseminating to secondary sites is still actively debated and hybrid states are presently considered as more relevant during tumor progression and metastasis. Here, we describe an unexplored role of EMT on the tumor microenvironment by controlling tumor innervation. Using in vitro and in vivo breast tumor progression models, we demonstrat

SUBMITTER: Grelet S 

PROVIDER: S-EPMC8645334 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature