Temporal and sequential order of nonoverlapping gene networks unraveled in mated female Drosophila.

ABSTRACT: In this study, we reanalyzed available datasets of gene expression changes in female Drosophila head induced by mating. Mated females present metabolic phenotypic changes and display behavioral characteristics that are not observed in virgin females, such as repulsion to male sexual aggressiveness, fidelity to food spots selected for oviposition, and restriction to the colonization of new niches. We characterize gene networks that play a role in female brain plasticity after mating using AMINE, a novel algorithm to find dysregulated modules of interacting genes. The uncovered networks of altered genes revealed a strong specificity for each successive period of life span after mating in the female head, with little conservation between them. This finding highlights a temporal order of recru

SUBMITTER: Pasquier C 

PROVIDER: S-EPMC8645335 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature