Proteomic Analysis of Human Serum for Patients at Different Pathological Stages of Hepatic Fibrosis.

ABSTRACT:

Background

Hepatic fibrosis is a severe liver disease that has threatened human health for a long time. In order to undergo timely and adequate therapy, it is important for patients to obtain an accurate diagnosis of fibrosis. Laboratory inspection methods have been efficient in distinguishing between advanced hepatic fibrosis stages (F3, F4), but the identification of early stages of fibrosis has not been achieved. The development of proteomics may provide us with a new direction to identify the stages of fibrosis.

Methods

We established serum proteomic maps for patients with hepatic fibrosis at different stages and identified differential expression of proteins between fibrosis stages through ultra-high-performance liquid chromatography tandem mass spectrometry proteomic a

SUBMITTER: Zhao K 

PROVIDER: S-EPMC8645358 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature