Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma.

ABSTRACT:

Background

Cigarette smoking and Th2-inflammation are both crucial in the pathogenesis of asthma. However, it is unknown whether smoking can affect the association between Th2-inflammation and small airway obstruction in adults with asthma.

Methods

Adults diagnosed with asthma by a pulmonologist according to Global Initiative for Asthma guidelines were recruited from September 2016 to April 2018 to participate in this study. Participants were divided into two groups, the small airway obstruction group (those with FEF25-75% predicted value ≤ 65%) and the normal small airway function group (those with FEF25-75% predicted value > 65%). Final data analysis included 385 and 93 people in the Obstructive Group and the Normal Group, respectively. Total serum IgE level and blood eosi

SUBMITTER: Chu S 

PROVIDER: S-EPMC8645388 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature