TRPM7 N-terminal region forms complexes with calcium binding proteins CaM and S100A1.

ABSTRACT: Transient receptor potential melastatin 7 (TRPM7) represents melastatin TRP channel with two significant functions, cation permeability and kinase activity. TRPM7 is widely expressed among tissues and is therefore involved in a variety of cellular functions representing mainly Mg2+ homeostasis, cellular Ca2+ flickering, and the regulation of DNA transcription by a cleaved kinase domain translocated to the nucleus. TRPM7 participates in several important biological processes in the nervous and cardiovascular systems. Together with the necessary function of the TRPM7 in these tissues and its recently analyzed overall structure, this channel requires further studies leading to the development of potential therapeutic targets. Here we present the first study investigating the N-termini of TRPM

SUBMITTER: Bousova K 

PROVIDER: S-EPMC8645431 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature