Polygenic risk scores for alcohol involvement relate to brain structure in substance-naive children: Results from the ABCD study.

ABSTRACT: Brain imaging-derived structural correlates of alcohol involvement have largely been speculated to arise as a consequence of alcohol exposure. However, they may also reflect predispositional risk. In substance naïve children of European ancestry who completed the baseline session of the Adolescent Brain Cognitive Development (ABCD) Study (n = 3013), mixed-effects models estimated whether polygenic risk scores (PRS) for problematic alcohol use (PAU-PRS) and drinks per week (DPW-PRS) are associated with magnetic resonance imaging-derived brain structure phenotypes (i.e., total and regional: cortical thickness, surface area and volume; subcortical volume; white matter volume, fractional anisotropy, mean diffusivity). Follow-up analyses evaluated whether any identified regions were also associ

SUBMITTER: Hatoum AS 

PROVIDER: S-EPMC8645657 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature