Emerging treatment evolutions and integrated molecular characteristics of biliary tract cancers.

ABSTRACT: Biliary tract cancers (BTCs) consist of a group of highly heterogeneous malignancies that are characterized by genomic differences among tumors from different anatomic sites. The current treatment for BTC includes surgery, chemotherapy, target therapy, and immunotherapy. Although surgery remains the primary option for localized disease, representing the only potential curative treatment, a high risk of recurrence cannot be neglected. Chemotherapy has been considered the standard of care for both advanced and metastatic disease and in adjuvant settings. However, drug resistance is a major obstacle associated with chemotherapy. The development of genetic testing technologies, including next-generation sequencing, has opened the door for the identification of drug targets and candidate molecu

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8645726 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature