Prediction of the effects of radiation therapy in esophageal cancer using diffusion and perfusion MRI.

ABSTRACT: Chemoradiation therapy (CRT) of locally advanced esophageal cancer (LAEC), although improving outcomes of patients, still results in 50% of local failure. An early prediction could identify patients at high risk of poor response for individualized adaptive treatment. We aimed to investigate physiological changes in LAEC using diffusion and perfusion magnetic resonance imaging (MRI) for early prediction of treatment response. In the study, 115 LAEC patients treated with CRT were enrolled (67 in the discovery cohort and 48 in the validation cohort). MRI scans were performed before radiotherapy (pre-RT) and at week 3 during RT (mid-RT). Gross tumor volume (GTV) of primary tumor was delineated on T2-weighted images. Within the GTV, the hypercellularity volume (V_HC ) and high blood v

SUBMITTER: Wang P 

PROVIDER: S-EPMC8645758 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature