HR-MS Based Untargeted Lipidomics Reveals Characteristic Lipid Signatures of Wilson's Disease.

ABSTRACT: Background and Aims: The diagnosis of Wilson's disease (WD) is challenging by clinical or genetic criteria. A typical early pathological change of WD is the increased liver lipid deposition and lowered serum triglyceride (TG). Therefore, the contents of serum lipids may provide evidence for screening of biomarkers for WD. Methods: 34 WD patients, 31 WD relatives, and 65 normal controls were enrolled in this study. Serum lipidomics data was acquired by an ultra-high-performance liquid chromatography high-resolution mass spectrometry system, and the data were analyzed by multivariate statistical methods. Results: Of all 510 identified lipids, there are 297 differential lipids between the WD and controls, 378 differential lipids between the relatives and controls, and 119

SUBMITTER: Zhi Y 

PROVIDER: S-EPMC8645799 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature