Production and Composition of Group B Streptococcal Membrane Vesicles Vary Across Diverse Lineages.

ABSTRACT: Although the neonatal and fetal pathogen Group B Streptococcus (GBS) asymptomatically colonizes the vaginal tract of ∼30% of pregnant women, only a fraction of their offspring develops invasive disease. We and others have postulated that these dimorphic clinical phenotypes are driven by strain variability; however, the bacterial factors that promote these divergent clinical phenotypes remain unclear. It was previously shown that GBS produces membrane vesicles (MVs) that contain active virulence factors capable of inducing adverse pregnancy outcomes. Because the relationship between strain variation and vesicle composition or production is unknown, we sought to quantify MV production and examine the protein composition, using label-free proteomics on MVs produced by diverse clinical

SUBMITTER: McCutcheon CR 

PROVIDER: S-EPMC8645895 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature