Gut-Evolved Candida albicans Induces Metabolic Changes in Neutrophils.

ABSTRACT: Serial passaging of the human fungal pathogen Candida albicans in the gastrointestinal tract of antibiotics-treated mice selects for virulence-attenuated strains. These gut-evolved strains protect the host from infection by a wide range of pathogens via trained immunity. Here, we further investigated the molecular and cellular mechanisms underlying this innate immune memory. Both Dectin-1 (the main receptor for β-glucan; a well-described immune training molecule in the fungal cell wall) and Nod2 (a receptor described to mediate BCG-induced trained immunity), were redundant for the protection induced by gut-evolved C. albicans against a virulent C. albicans strain, suggesting that gut-evolved C. albicans strains induce trained immunity via other pat

SUBMITTER: Reales-Calderon JA 

PROVIDER: S-EPMC8645939 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature