Asthma as a risk factor for hospitalization in children with COVID-19: A nested case-control study.

ABSTRACT:

Background

Most pediatric studies of asthma and COVID-19 to date have been ecological, which offer limited insight. We evaluated the association between asthma and COVID-19 at an individual level.

Methods

Using data from prospective clinical registries, we conducted a nested case-control study comparing three groups: children with COVID-19 and underlying asthma ("A+C" cases); children with COVID-19 without underlying disease ("C+" controls); and children with asthma without COVID-19 ("A+" controls).

Results

The cohort included 142 A+C cases, 1110 C+ controls, and 140 A+ controls. A+C cases were more likely than C+ controls to present with dyspnea and wheezing, to receive pharmacologic treatment including systemic steroids (all p < .01), and to be hospitalized (4.9% vs

SUBMITTER: Gaietto K 

PROVIDER: S-EPMC8646549 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature